魁蒿化学成分及药理活性研究进展

doi:10.13438/j.cnki.jdzk.2020.02.011

摘要/Abstract

摘要：

根据近年来国内外最新研究文献，对魁蒿化学成分及药理作用研究进展进行了综述，并展望了未来的研究方向，为合理开发利用魁蒿植物资源提供参考.已有的研究表明，魁蒿化学成分以挥发性化合物数目最多，其次为黄酮类化合物和糖类化合物，具有抗炎、抗癌、抗皮肤瘙痒、抗过敏、抗氧化、降血脂、保胃、抗溃疡等作用，具有广阔的药用前景.

关键词： 魁蒿, 化学成分, 药理作用

Abstract:

Recent researches on the chemical components and pharmacological effects of Artemisia princeps are reviewed, and the research directions are suggested. It is shown that the chemical components of Artemisia princeps are mostly volatile compounds, followed by flavonoids and carbohydrates, which have anti-inflammatory, anti-cancer, anti-itch, anti-allergic, anti-oxidation, anti-ulcer, hypolipidemic, stomach-tonifying effects, endowing Artemisia princeps with great medicine prospect.

Key words: Artemisia princeps, chemical composition, pharmacological action

陈加蓓，陈功锡. 魁蒿化学成分及药理活性研究进展[J]. 吉首大学学报（自然科学版）, DOI: 10.13438/j.cnki.jdzk.2020.02.011.

CHEN Jiabei， CHEN Gongxi. Advances in Research on Chemical Components and Pharmacological Activities of Artemisia Princeps[J]. Journal of Jishou University（Natural Sciences Edition), DOI: 10.13438/j.cnki.jdzk.2020.02.011.

参考文献

[1] 周利娟，桑晓清，孙永艳，等.蒿属植物的农药活性及其有效成分[J].江西农业大学学报，2012，34(4)：699-705.
[2] 杨胜香，田启建，梁士楚，等.湘西花垣矿区主要植物种类及优势植物重金属蓄积特征[J].环境科学，2012，33(6)：2038-2045.
[3] 汪开治.魁蒿叶多酚可对离体脂类过氧化作用产生抗氧化活性[J].生物技术通报，2006(6)：126-126.
[4] 陈璇，张幸，陈功锡.湘西蒿菜粑粑原料植物及生产工艺研究[J].湖北民族学院学报(自然科学版)，2015，33(1)：85-90.
[5] 李刚凤，廖雪媛，李丽，等.魁蒿馒头加工工艺研究[J].食品研究与开发，2017，38(11)：81-84.
[6] 国家中医药管理局《中华本草》编委会.中华本草：第十九卷 [M].上海：上海科学技术出版社，1999：668.
[7] UMANO K, HAGI Y, NAKAHARA K, et al. Volatile Chemicals Identified in Extracts from Leaves of Japanese Mugwort ( Artemisia Princeps Pamp.)[J]. Journal of Agricultural and Food Chemistry, 2000, 48(8): 3463-3469.
[8] 潘炯光,徐植灵,吉力.艾叶挥发油的化学研究[J].中国中药杂志,1992(12):741-744；764.
[9] 杨杰波，唐小娅，陈伟强.α-蒎烯及其衍生物生物活性研究进展[J].中国处方药，2015(9)：12-13.
[10] 黄巧娟，孙志高，龙勇，等.D-柠檬烯抗癌机制的研究进展[J].食品科学,2015,36(7)：240-244.
[11] 车玉红，吴津蓉，郭春苗，等.基于SPME-GC-MS法分析4种榅桲果实香气成分[J].中国农学通报，2017，33(19)：158-164.
[12] 李晓光，叶富强，徐鸿华.砂仁挥发油中乙酸龙脑酯的药理作用研究[J].华西药学杂志，2001，16(5)：356-358.
[13] 陈涛，余楚国，夏雪奎，等.山稔子挥发油化学组成研究[J].中山大学学报(自然科学版)，2007，46(6)：135-137.
[14] 王茜莎，杨威，李明，等.δ-榄香烯体内外抗肿瘤作用研究[J].中国药房，2009(9)：650-653.
[15] 赵志梅，张立杰，夏天，等.莪术主要单体成分抗炎、抗肿瘤作用研究进展[J].药物评价研究，2017，40(1)：119-124.
[16] 周晓叶，蒋细旺，镇鸿燕.菊花挥发油主要成分对肿瘤抗性的研究进展[J].江汉大学学报(自然科学版)，2015，43(4)：376-381.
[17] 李长格.紫苏叶水浸膏及紫苏醛对神经系统的作用[J].现代药物与临床，1982(2)：39.
[18] 康建波.玉米油合成亚油酸乙酯试验研究[D].长春：吉林大学，2013.
[19] 邱电，张魁华，方炳虎.丁香酚的药理作用[J].动物医学进展，2007，28(8)：101-103.
[20] 张公亮，丁佳琦，董伟峰，等.几种硫醚类香料抑菌活性的研究[J].食品工业科技，2012，33(9)：127-130.
[21] SUBRAHMANYAM M, KULKARNI S T, RAMA A V. Catalyst Preparation Studies for the Synthesis of 2-Methylpyrazinet[J]. Indian Journal of Chemical Technology, 1995(2): 237-240．
[22] YAMADA H, OTSUKA Y, OMURA S. Structural Characterization of Anti-Complementary Polysaccharides from the Leaves of Artemisia Princeps[J]. Planta Medica, 1986, 52(4): 311-314.
[23] RA K S,YAMADA H, SUNG H J, et al. Purification and Chemical Properties of Anti-Complementary Polysaccharide from Capsici Fructus[J]. Journal of the Korean Agricultural Chemical Society, 1989, 32(4): 378-385.
[24] YAMADA H, OHTANI K, KIYOHARA H, et al. Purification and Chemical Properties of Anti-Complementary Polysaccharide from the Leaves of Artemisia Princeps[J]. Planta Medica, 1985, 51(2): 121-125.
[25] KYUNGSOOK C, JUNGHYE C, NAMIN B, et al. Eupafolin, a Flavonoid Isolated from Artemisia Princeps, Induced Apoptosis in Human Cervical Adenocarcinoma Hela Cells[J]. Molecular Nutrition & Food Research, 2010, 54(9): 1318-1328.
[26] CHO J H, LEE J G, YANG Y I, et al. Eupatilin, a Dietary Flavonoid, Induces G2/M Cell Cycle Arrest in Human Endometrial Cancer Cells[J]. Food & Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association, 2011, 49(8): 1737-1744.
[27] MIN S W, KIM N J, BAEK N I. Inhibitory Effect of Eupatilin and Jaceosidin Isolated from Artemisia Princeps on Carrageenan-Induced Inflammation in Mice[J]. Journal of Ethnopharmacology, 2009, 125(3): 497-500.
[28] RYU J H, LEE H J, JEONG Y S, et al. Yomogin, an Inhibitor of Nitric Oxide Production in LPS-Activated Macrophages[J]. Archives of Pharmacal Research, 1998, 21(4): 481-484.
[29] TRINH H T, LEE I A, HYUN Y J, et al. Artemisia Princeps Pamp. Essential Oil and Its Constituents Eucalyptol and 〖AKI^〗±-Terpineol Ameliorate Bacterial Vaginosis and Vulvovaginal Candidiasis in Mice by Inhibiting Bacterial Growth and Nf-〖AKI^〗Ob Activation[J]. Planta Medica, 2011, 77(18): 1996-2002.
[30] CHOI E J, KIM G H. Antioxidant and Anticancer Activity of Artemisia Princeps var. Orientalis Extract in Hepg2 and Hep3B Hepatocellular Carcinoma Cells[J]. Chinese Journal of Cancer Research, 2013, 25(5): 536-543.
[31] 沈嘉.魁蒿的细胞毒成分[J].中草药,1998(4):284-285.
[32] 戴垚，贺晓波.魁蒿内酯与1,25-二羟基维生素D3或全反式维甲酸协同诱导HL-60细胞分化的作用[J].现代药物与临床，2004，19(2):75-75.
[33] HAN H Y, KIM H J, JEONG S H, et al. The Flavonoid Jaceosidin from Artemisia Princeps Induces Apoptotic Cell Death and Inhibits the Akt Pathway in Oral Cancer Cells[J]. Evidence-Based Complementary and Alternative Medicine, 2018, 2018: 1-9.
[34] LEE J G, KIM J H, AHN J H, et al. Jaceosidin, Isolated from Dietary Mugwort (Artemisia Princeps), Induces G2/M Cell Cycle Arrest by Inactivating cdc25C-cdc2 via ATM-Chk1/2 Activation[J]. Food & Chemical Toxicology, 2013, 55(3): 214-221.
[35] 冰华.含魁蒿提取物的抗瘙痒药[J].现代药物与临床,1991(2):95.
[36] HIRANO A, GOTO M, MITSUI T, et al. Antioxidant Artemisia Princeps Extract Enhances the Expression of Filaggrin and Loricrin via the AHR/OVOL1 Pathway[J]. International Journal of Molecular Sciences, 2017, 18(9): 1948.
[37] LEE S H, SHIN Y W, BAE E A, et al. Lactic Acid Bacteria Increase Antiallergic Effect of Artemisia Princeps Pampanini SS-1[J]. Archives of Pharmacal Research, 2006, 29(9): 752-756.
[38] LEE S H, BAE E A, PARK E K, et al. Inhibitory Effect of Eupatilin and Jaceosidin Isolated from Artemisia Princeps in IgE-Induced Hypersensitivity[J]. International Immunopharmacology, 2007, 7(13): 1678-1684.
[39] CHUNG M J, KANG AY, PARK S O, et al. The Effect of Essential Oils of Dietary Wormwood (Artemisia Princeps), with and Without Added Vitamin E, on Oxidative Stress and Some Genes Involved in Cholesterol Metabolism[J]. Food & Chemical Toxicology, 2007, 45: 1400-1409.
[40] MASUTANI H, OTSUKI R, YAMAGUCHI Y, et al. Fragrant Unsaturated Aldehydes Elicit Activation of the Keap1/Nrf2 System Leading to the Upregulation of Thioredoxin Expression and Protection Against Oxidative Stress[J]. Antioxid Redox Signal, 2009, 11: 949-962.
[41] AKIHISA T, KAWASHIMA K, ORIDO M, et al. Antioxidative and Melanogenesis-Inhibitory Activities of Caffeoylquinic Acids and Other Compounds from Moxa.[J]. Chemistry & Biodiversity, 2013, 10(3):313-327.
[42] HWANG K E, KIM H W, CNOI Y S, et al. Evaluation of the Antioxidant Effect of Ganghwayakssuk (Artemisia Princeps Pamp.) Extract Alone and in Combination with Ascorbic Acid in Raw Chicken Patties[J]. Poultry Science, 2013, 92(12): 3244-3250.
[43] ZHANG J, SASAKI T, LI W, et al. Identification of Caffeoylquinic Acid Derivatives as Natural Protein Tyrosine Phosphatase 1B Inhibitors from Artemisia Princeps[J]. Bioorganic & Medicinal Chemistry Letters, 2018, 28(7): 1194-1197.
[44] YAMAMOTO N, KANEMOTO Y, UEDA M, et al. Anti-Obesity and Anti-Diabetic Effects of Ethanol Extract of Artemisia Princeps in C57Bl/6 Mice Fed a High-Fat Diet[J]. Food & Function, 2011, 2(1): 45-52.
[45] HOP H T, ARAYAN L T, REYES A, et al. Inhibitory Effect of an Ethanol Extract of a Rice Bran Mixture Comprising Angelica Gigas, Cnidium Officinale, Artemisia Princeps, and Camellia Sinensis on Brucella Abortus Uptake by Professional and Nonprofessional Phagocytes[J]. Journal Microbiol Biotechnol, 2017, 27(10): 1885-1891.
[46] PARK E Y, LEE K W, LEE H W, et al. The Ethanol Extract from Artemisia Princeps Pampanini Induces P53-Mediated G1 Phase Arrest in A172 Human Neuroblastoma Cells[J]. Journal of Medicinal Food, 2008, 11(2): 237-245.
[47] CHOI N Y, KANG S Y, KIM K J. Artemisia Princeps Inhibits Biofilm Formation and Virulence-Factor Expression of Antibiotic-Resistant Bacteria[J]. Biomed Research International, 2015, 2015(6): 239519.
[48] CHO S H, NA Y E, AHN Y J. Growth-Inhibiting Effects of Seco-Tanapartholides Identified in Artemisia Princeps var. Orientalis Whole Plant on Human Intestinal Bacteria[J]. Journal of Applied Microbiology, 2003, 95(1): 7-12.
[49] CHEN P, LI Z, HU Y. Prevalence of Osteoporosis in China: A Meta-Analysis and Systematic Review[J]. BMC Public Health, 2016, 16(1): 1039.
[50] CHO H J, KIM J W, JU S Y, et al. Effects of Artemisia Princeps Supplementation on Bone Metabolism in Ovariectomized Rats[J]. Journal of Nutrition Health & Aging, 2016, 20(5): 533-539.
[51] KIM J Y, LEE M S, BAEK J M, et al. Massive Elimination of Multinucleated Osteoclasts by Eupatilin is Due to Dual Inhibition of Transcription and Cytoskeletal Rearrangement[J]. Bone Reports, 2015, 3(S2): 83-94.
[52] HIRANO A, GOTO M, MITSUI T, et al. Antioxidant Artemisia Princeps Extract Enhances the Expression of Filaggrin and Loricrin via the AHR/OVOL1 Pathway[J].International Journal of Molecular Sciences, 2017, 18(9): 1948.
[53] 山口贵世志，怡悦.植物雌激素对血管内皮依赖性弛缓反应的影响[J].国际中医中药杂志，2004，26(1):38.
[54] 历强，马建仓.芹菜素的药理学研究进展[J].国外医学(中医中药分册)，2003，25(3):147-149.
[55] RYU J H, LEE H J, JEONG Y S, et al. Yomogin, an Inhibitor of Nitric Oxide Production in LPS-Activated Macrophages[J]. Archives of Pharmacal Research, 1998, 21(4): 481-484.
[56] LEE T H, JUNG H, PARK K H, et al. Jaceosidin, a Natural Flavone, Promotes Angiogenesis via Activation of VEGFR2/FAK/PI3K/AKT/NF-κB Signaling Pathways in Endothelial Cells[J]. Experimental Biology & Medicine, 2014, 239(10): 1325-1334.
[57] RYU R, JUNG U J, KIM H J, et al. Anticoagulant and Antiplatelet Activities of Artemisia Princeps Pampanini and Its Bioactive Components[J]. Preventive Nutrition and Food Science, 2013, 18(3): 181-187.
[58] HAYAKAWA Y, HAYASHI T, HAYASHI T, et al. Selective Activation of Heparin Cofactor Ⅱ by a Sulfated Polysaccharide Isolated from the Leaves of Artemisia Princeps[J]. Blood Coagulation & Fibrinolysis An International Journal in Haemostasis & Thrombosis 1995, 6(7): 643-649.
[59] KIM J H, JUNG S H, YANG Y I, et al. Artemisia Leaf Extract Induces Apoptosis in Human Endometriotic Cells Through Regulation of the P38 and NfκB Pathways[J]. Journal of Ethnopharmacology, 2013, 145(3): 767-775.
[60] YANG H J, MIN J K, KWON D Y, et al. The Combination of Artemisia Princeps Pamp, Leonurus Japonicas Houtt, and Gardenia Jasminoides Ellis, Fruit Attenuates the Exacerbation of Energy, Lipid, and Glucose by Increasing Hepatic PGC-1α Expression in Estrogen-Deficient Rats[J]. BMC Complementary & Alternative Medicine, 2016, 16(1): 137.
[61] KIM H B, KWON B J, CHO H J, et al. Long-Term Treatment with Oriental Medicinal Herb Artemisia Princeps Alters Neuroplasticity in a Rat Model of Ovarian Hormone Deficiency[J]. Experimental Neurobiology, 2015, 24(1): 71-83.
[62] BAE E A, MIN S W, LEE B, et al. Antiasthmic Effect of Fermented Artemisia Princeps in Asthmic Mice Induced by Ovalbumin[J]. Journal of Microbiology & Biotechnology, 2007, 17(9): 1554-1557.
[63] KIM T H, LEE S J, RIM H K, et al. in Vitro and in Vivo Immunostimulatory Effects of Hot Water Extracts from the Leaves of Artemisia Princeps Pampanini Cv. Sajabal[J]. Journal of Ethnopharmacology, 2013, 149(1): 254-262.
[64] HAN Y, DING Y, XIE D, et al. Design, Synthesis, and Antiviral Activity of Novel Rutin Derivatives Containing 1, 4-Pentadien-3-One Moiety[J]. European Journal of Medicinal Chemistry, 2015, 92: 732-737.
[65] KOH C H, WONG L. Effect of Dietary Supplementation of Lactobacillus-Fermented Artemisia Princeps on Growth Performance, Meat Lipid Peroxidation, and Intestinal Microflora in Hy-Line Brown Male Chickens[J]. Poultry Science, 2012, 91(11): 2845-2851.
[66] LIU C H, MISHRA A K, TAN R X, et al. Repellent and Insecticidal Activities of Essential Oils from Artemisia Princeps and Cinnamomum Camphora and Their Effect on Seed Germination of Wheat and Broad Bean[J]. Bioresour Technol, 2006, 97(15): 1969-1973.
[67] YAMAMOTO N, UEDA M, KAWABATA K. Artemisia Princeps Extract Promoted Glucose Uptake in Cultured L6 Muscle Cells via Glucose Transporter 4 Translocation[J]. Bioscience Biotechnology & Biochemistry, 2010, 74(10): 2036-2042.