吉首大学学报(自然科学版) ›› 2021, Vol. 42 ›› Issue (5): 65-69.DOI: 10.13438/j.cnki.jdzk.2021.05.012

• 医学 • 上一篇    下一篇

US-CNB组织学诊断早期乳腺浸润性小叶癌的价值

杨波,关静文   

  1. (1.皖北卫生职业学院病理教研室,安徽 宿州 234000;2.宿州市立医院病理科,安徽 宿州 234000)
  • 出版日期:2021-09-25 发布日期:2022-01-18
  • 作者简介:杨波(1984—),男,硕士,安徽宿州人,讲师,主要从事临床病理和病理学教育研究.

Value of US-CNB Histology in the Diagnosis of Early Invasive Lobular Carcinoma of the Breast

YANG Bo, GUAN Jingwen   

  1. (1. Department of Pathology, Wanbei Health Vocational College, Suzhou 234000, Anhui China; 2. Department of Pathology, Suzhou Municipal Hospital, Suzhou 234000, Anhui China)
  • Online:2021-09-25 Published:2022-01-18

摘要:探讨超声引导下粗针穿刺(US-CNB)组织学检查应用在早期乳腺浸润性小叶癌(ILC)的诊断价值.于2019年10月至2020年10月选择安徽省皖北地区某三甲医院乳腺外科确诊的169例早期乳腺癌患者作为研究对象,术后组织病理学结果(金标准):早期ILC 65例,其他早期乳腺癌患者104例.患者在术前均在超声引导下进行细针穿刺(US-FNAC)与US-CNB组织学检查,与术后病理检查结果进行对比,记录US-FNAC与US-CNB诊断早期ILC价值以及所有患者进行US-CNB检测后雌激素受体(ER)、孕激素受体(PR)、人类表皮生长因子受体-2(HER-2)的阳性表达率.经US-FNAC诊断为早期ILC的患者有46例,其他早期乳腺癌的患者123例.经US-CNB诊断为早期ILC的患者有57例,其他早期乳腺癌的患者112例,US-CNB诊断早期ILC的敏感度84.65%显著高于US-FNAC的68.18%(P<0.05),但两种检测方式的准确度和特异度对比无统计学意义(P>0.05);经US-CNB组织学诊断后,早期ILC患者的HER-2阳性表达率显著高于其他早期乳腺癌患者(P<0.05),ER、PR阳性表达率与其他早期乳腺癌患者对比无统计学意义(P>0.05).US-CNB组织学检查诊断早期ILC的敏感性较好,患者HER-2的阳性表达率高.

关键词: US-CNB组织学, 早期乳腺浸润性小叶癌, 诊断价值

Abstract: Objective To analyze the value of ultrasound-guided thick needle aspiration (US-CNB) histological examination in the diagnosis of early invasive lobular carcinoma (ILC) of the breast. Methods 169 patients with early breast cancer diagnosed in the breast surgery department of a third-class hospital in Wanbei, Anhui Province between October 2019 and October 2020 were selected as the research objects. Postoperative histopathological results (gold standard): early breast ILC 65 Cases, 104 other early breast cancer patients. All patients underwent ultrasound-guided fine-needle aspiration (US-FNAC) and US-CNB histological examinations before surgery, compared with postoperative pathological examination results, and recorded the value of US-FNAC and US-CNB in the diagnosis of early breast ILC, and all patients Comparison of the positive expression rates of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER-2) tested by US-CNB. Results US-FNAC diagnosed 46 patients with early breast ILC and 123 other patients with early breast cancer. US-CNB diagnosed early breast ILC in 57 cases and 112 other early breast cancer patients. The sensitivity of US-CNB in diagnosing early breast ILC was 84.65% higher than that of US-FNAC 68.18% (P<0.05), but The accuracy and specificity of the two detection methods were not statistically significant (P>0.05); the positive expression rate of HER-2 in early breast ILC patients was higher than that in other early breast cancer patients (P<0.05), and the positive expression of ER and PR Compared with other early breast cancer patients, the rate was not statistically significant (P>0.05). Conclusion US-CNB histological examination has good sensitivity in diagnosing early breast ILC, and the positive expression rate of HER-2 in patients is high.

Key words: US-CNB histological examination, early invasive lobular carcinoma of the breast, diagnostic value

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