鱼用含睾酮的明胶- 羧甲基纤维素钠微囊制剂

journal6 ›› 2001, Vol. 22 ›› Issue (4): 23-28.

鱼用含睾酮的明胶- 羧甲基纤维素钠微囊制剂

(浙江大学饲料科学研究所, 浙江杭州 310029)

出版日期:2001-12-15 发布日期:2013-01-05
作者简介:邓岳松( 1967- ) ,男, 湖南省长沙市人,博士, 浙江大学饲料科学研究所讲师, 主要从事水生生物学研究.
基金资助:
国家自然科学基金资助项目( 39770101)

Manufacture of the Gelatin- sodium Carboxymethyl Cellulose Microcapsule Containing Testosterone for Fish

( Feed Science Institute of Zhejiang University ,Hangzhou 310029, Zhejinag China)

Online:2001-12-15 Published:2013-01-05

摘要/Abstract

摘要：制备了含睾酮的明胶- 羧甲基纤维素钠微囊(TGM) , 对微囊的制备工艺进行了优化. TGM 睾酮的包囊率为( 71.8±0. 9) %,含药量为( 17. 4±0. 41) %.TGM 中药物释放数据符合零级释放规律.微囊的平均囊径为 29. 5 μm. 用微囊对鳗鲡进行注射催熟实验, 间隔 25 d 注射1次, 80% 的雄鳗达到性成熟. 间隔 25 d 注射 TGM 4 次, 可诱导雌鳗平均GSI达到19.7%,最高 GSI为 34. 1%.

关键词： 明胶- 羧甲基纤维素钠, 微囊, 睾酮, 鳗鲡

Abstract: The manufacture of microcapsule using Gelatin-sodium Carboxymethyl Cellulose as coating material and testosterone as core material(TGM) is introduced. The average diameters of microcapsule was determined to be 29. 5 μm.The mean drug loading in microcapsule was assayed to be ( 71. 8±0.9) % for TGM. In vitrorelease show after burst release in first few days, the drugrelease from microcapsule was obeyed zero-order. The testees of male Japanese eel were achieved maturation by injection TGM at the interval of 25 d. The mean GSI of female eel were reached 19. 7% by injection TGM four times at the interval of 25 d.

Key words: gelatin-sodium carboxymethyl cellulose, microcapsule, testosterone, Japanese eel

邓岳松. 鱼用含睾酮的明胶- 羧甲基纤维素钠微囊制剂[J]. journal6, 2001, 22(4): 23-28.

DENG Yue-Song. Manufacture of the Gelatin- sodium Carboxymethyl Cellulose Microcapsule Containing Testosterone for Fish[J]. journal6, 2001, 22(4): 23-28.