参脉注射液对Ⅱ型糖尿病肾病患者血液CRP与黏附分子的影响

journal6 ›› 2010, Vol. 31 ›› Issue (1): 113-115.

参脉注射液对Ⅱ型糖尿病肾病患者血液CRP与黏附分子的影响

（1.湘西自治州中心血站，湖南吉首 416000；2.湘西自治州人民医院，湖南吉首 416000）

出版日期:2010-01-25 发布日期:2012-04-19
作者简介:彭勤（1971-）,女,湖南永顺人，湘西自治州中心血站主管检验师，主要从临床检验及输血研究.

Effect of Salvia Miltiorrhiza Injection on CRP and Adhesion Molecule in the Type Ⅱ Diabetic Nephropathy Patient Blood

(1.Central Blood Station of Xiangxi Autonomous Prefecture,Jishou,416000,Hunan China;2.The People's Hospital of Xiangxi Autonomous Prefecture,Jishou 416000,Hunan China)

Online:2010-01-25 Published:2012-04-19

摘要/Abstract

摘要：为观察参脉注射液对Ⅱ型糖尿病肾病患者血液CRP与粘附分子P-sel和ICAM-1的影响，探讨中西医结合治疗Ⅱ型糖尿病肾病的机制,采用参脉注射液治疗38例患者，取常规西药组43例作为对比观察，于治疗前后检测患者血液中CRP和粘附分子P-sel和ICAM-1水平.结果表明：参脉注射液治疗Ⅱ型糖尿病肾病总有效率68.4%，而对照组总有效率为46.5%，2组比较差异有显著性；治疗前参脉注射液治疗组CRP与P-sel和ICAM-1水平与西药治疗对照组比较差异无显著性；治疗后2组CRP与P-sel和ICAM-1水平均显著降低，但参脉注射液治疗组下降更为明显，与西药治疗组比较差异有显著性.说明参脉注射液结合西药治疗对Ⅱ型糖尿病肾病有显著疗效，可能与参脉注射液调节炎性细胞活性、抑制炎症反应有关.

关键词： 参脉注射液, C-反应蛋白, P-sel, ICAM-1, Ⅱ型糖尿病肾病

Abstract: To observe the effect of salvia miltiorrhiza injection on CRP,P-sel and ICAM-1 in the blood of Type Ⅱ diabetic nephropathy patient and to approach the mechanism of conbined treatment of traditional Chinese medicine and Western medicine for the type Ⅱ diabetic nephropathy，salvia miltiorrhiza injection was applied to treat 38 patients with typeⅡ diabetic nephropathy,and another 43 patients were used as contrasts treated by routine Western medicine.The content of CRP,P-sel and ICAM-1 in the blood of patients were detected both before and after the treatment.The results showed that the total effective rate of salvia miltiorrhiza injection treatment for type Ⅱ diabetic nephropathy was 68.4%,and that of the contrast group was 46.5%.There was significant difference between them.Before treatment the levels of CRP，P-sel and ICAM-1 between salvia miltiorrhiza injection group and Western medicine contrast group had no significant difference,but after treatment there was statistical difference between them,and the levels of CRP，P-sel and ICAM-1 molecule in the group cured by salvia miltiorrhiza injection were lower than that of contrast group.It can be concluded that there is significant curative effect of salvia miltiorrhiza injection treatment for type Ⅱ diabetic nephropathy patients.Probably the mechanism of treatment is that salvia miltiorrhiza injection can down regulate inflammatory cell activity and inhibite inflammatory reaction.

Key words: salvia miltiorrhiza injection, CRP, P-sel, intercellular adhesion molecule, type Ⅱ diabetic nephropathy

彭勤, 向敏, 龙书云, 陈莉莉. 参脉注射液对Ⅱ型糖尿病肾病患者血液CRP与黏附分子的影响[J]. journal6, 2010, 31(1): 113-115.

PENG Qin, XIANG Min, LONG Shu-Yun, CHEN Li-Li. Effect of Salvia Miltiorrhiza Injection on CRP and Adhesion Molecule in the Type Ⅱ Diabetic Nephropathy Patient Blood[J]. journal6, 2010, 31(1): 113-115.