journal6 ›› 2015, Vol. 36 ›› Issue (2): 60-70.DOI: 10.3969/j.issn.1007-2985.2015.02.013

• Biological and chemical • Previous Articles     Next Articles

Recent Progress on Radical C—H Bond Cyclization to Form Oxindoles

 ZHOU  Dong, LI  Yu-Hua, DENG  You-Lin, LI  Zhi-Hao- , TANG  Shi   

  1. (1.College of Chemistry and Chemical Engineering,Jishou University,Jishou 416000,Hunan China;2.College of Chemistry and Chemical Engineering,Central South University,Changsha 410083,China)
  • Online:2015-03-25 Published:2015-04-28

Abstract: Oxindole and its derivatives are widely distributed in nature,and the synthetic method has been one of the hot topics of synthetic chemistry.According to the coupling mechanism,the researches on oxindole synthesis through free radical mediated C—H cyclization in recent years are summarized.In view of the effects of catalyst,oxidizing agent,and solvent on the reaction system,this paper discusses the method of cleaving C—H bond.

Key words: free radical, C&mdash, H oxidation, tandem reaction, oxidant

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